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7 Tesla, passively shielded MR System for Human Studies

CMRR has established the first 7 Tesla MRI scanner in the world in 1999, based on a 90 cm bore, passively shielded magnet from Magnex Scientific, currently part of Agilent Corp. System integration was performed by CMRR staff from components acquired from various vendors. The work performed on this system pioneered ultrahigh field MRI based on 7 Tesla, leading to introduction of commercial systems from major manufacturers of human MRI scanners (Siemens, GE and Philips), and the current drive to use 7T as the most advanced platform for human research. With the availability of advanced systems from commercial manufacturers, this first ever 7T system was converted to Siemens electronics. Currently, it serves as one of the two 7T systems that are heavily used by CMRR scientists and collaborators. Its development was funded by NCRR High End Instrumentation grant, BTRC equipment funds, Keck foundation and University of Minnesota.

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7 Tesla MR System for Human Studies based on 90 cm bore actively shielded magnet.

Commensurate with the increased role played by 7 T systems in biomedical research both in the brain and in the body, a second 7T system was established in 2011 and is currently operational, supporting core research, as well as collaborative and service projects.

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Psychophysics Lab / Eyetracking at 7T

The NEI Vision Core Grant sponsors a psychophysics lab hosted at the CMRR. This facility offers a state of the art psychophysics station with eyetracking available at both 7T systems.

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4 Tesla MR system for Human studies, based on a 90 cm bore unshielded magnet

High field MR imaging and spectroscopy started when three academic laboratories in the US installed 4 Tesla human systems. One of those was CMRR. Of these systems, this 4T is the only one that has survived and is currently used heavily for spectroscopy studies in humans. Because of its open programming environment (Varian, now acquired by Agilent), it is also the system used for development and application of unusual and novel imaging sequences.

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3T-A Siemens MAGNETOM Primsa with Tim 4G Technology

This is standard 3T, identical to those used in hospitals for clinical diagnosis. It is dedicated to research use and serves a large community of investigators, mainly for brain research that includes cognitive neurosciences, psychiatric diseases, child development etc. It is heavily used as a service instrument and the two 3T instruments together support more than sixty projects currently.

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3T-B Siemens MAGNETOM Prisma with Tim 4G Technology

The 3T-B system was acquired in 2012 and upgraded to a Siemens Prisma in March 2014. This is a state-of-the-art, FDA-approved scanner with advanced imaging capabilities, including 128 receive channels. The Prisma scanner serves the basic and translational MRI imaging needs for researchers across the University, as well as business partners from the Twin Cities medical device industry.

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10.5T / 89 cm Bore system for human studies.

Funded by NCRR High End Instrumentation grant and University of Minnesota, this system is under development. Magnet installation was completed in 2014. It will be the highest field whole body MRI system in the world and will be used to for both brain studies and for the human torso. Understanding of electromagnetic wave behavior in the body at such frequencies and multichannel transmit technology developed in this BTRC will enable the exploration of such high magnetic fields in biomedical research for the first time.

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9.4T/31 cm bore MR system for Animal Model studies

This is a dedicated MRI system for animal model studies and is the workhorse for such experiments in this BTRC. It was the first such high field magnet with a horizontal bore suitable for animal model studies; as such, it pioneered the most commonly employed animal MRI/MRS system currently. The work conducted on this system justified the development of high field scanners, namely the 7T scanner, for human research.

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9.4T/65 cm bore MR system for Animal Model studies

This system is utilized for large animal model studies, particularly for cardiac experiments and is also suitable for human head imaging. It was one of the two efforts initiated to explore magnetic fields beyond 7 T for human imaging, the other being in University of Illinois at Chicago. It is also one of the few systems with multichannel transmit capability, and as such is utilized for technique development.

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16.4 Tesla, 26 cm Bore system for animal model studies

This recent addition to CMRR is the highest field available in the United states for animal model studies and the only one of its kind.

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Electronics Shop

CMRR is equipped with a large electronics shop that supports the manufacturing of complex RF coils employed in all aspects of MRI technology development.

Computational Resources

CMRR is equipped with extensive computational resources. Onsite file servers and compute servers are located in a modern secured server room with diesel-backed UPS power and fully redundant cooling.

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Siemens Inveon microPET/CT

A Siemens Inveon preclinical microPET/CT now augments the center's extensive MR capabilities. microPET/CT is a molecular level functional imaging modality that provides valuable insight into biochemical, physiological, pathological and/or pharmacological processes in vivo.  This system is currently administred by the University Imaging Center; and for more information on using it please go to: http://uic.umn.edu/equipment/siemens-inveon-micropetct

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Oxford Instruments HyperSense Hyperpolarizer

Located near the 9.4-T, 31-cm horizontal bore magnet, the Oxford Instruments HyperSense enables a more than 10,000-fold enhancement of 13C NMR signals in solution using dynamic nuclear polarization (DNP) technique and a rapid dissolution procedure.

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Siemens Biograph PET/CT

The Siemens Biograph mCt PET/CT scanner is the most advanced scanner in the state of Minnesota. With an onsite Cyclotron from PetNet, CCIR can deliver the most advance imaging techniques and studies available.

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Cyclotron - Siemens PETNET

The CMRR facility houses a Siemens Eclipse HP shielded cyclotron which is owned and operated by PETNET Solutions, a wholly owned subsidiary of Siemens Medical Solutions USA, Inc. This 4,051 sq. ft. facility is PETNET's Twin Cities manufacturing site of medical radioisotopes for University of Minnesota researchers and local hospitals and clinics.

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17.0 Tesla 5cm Vertical Bore

The magnet design incorporates a very strong field gradient (~ 100 T/m) near the top of the magnet which is necessary for magnetic levitation. Levitation occurs when the magnetic force counterbalances the gravitational force and thus simulates orbital freefall. This instrument will provide a unique environment to process organic and inorganic materials and investigate biological materials, living and non-living, in a simulated microgravity environment.

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Biostatistical Services

Biostatistics consultative services are available free of charge.

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Seminar Room

The CMRR has a fully-equipped seminar room available for hosting workshops and events.

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Subject Rooms

Support rooms are conveniently located in facility for consenting subjects, performing testing procedures and changing into gowns, as well as performing medical procedures, such as starting IV’s, monitoring vitals and administering medical testing.

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MR Technologist

MR Technologists are available to run 3T/7T scanners, assist with data collection, maintain equipment and troubleshoot scanner issues.

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