Faculty and Staff

Michael Garwood, Ph.D.

Professor
102B CMRR
612-626-2001

gar [at] cmrr (dot) umn (dot) edu

My objective is to develop and apply new non-invasive methods in nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) to research cancer. The general aim is to better understand the unique functional and molecular properties of cancer, and to improve the clinical management of the disease, by using MRS/MRI methodologies.

Current specific research goals are threefold:

To apply theoretical formalisms to describe the magnetic resonance phenomenon; in particular, the interaction between nuclear spins and a radiofrequency (RF) field having a variable amplitude (₁(t)) and frequency (_RF (t)) in time (t).
To exploit the unique properties of these frequency-modulated RF techniques to enhance sensitivity and data quality in MRI and MRS.
To expose molecular properties of cancers using MRI and MRS, and to use these for making diagnoses and for evaluating and guiding cancer treatments, all non-invasively.

Video of Dr. Garwood receiving ISMRM Gold Medal
High quality (wmv) 80mb
Medium quality (wmv) 7mb

Selected Recent Publications:

Transverse Relaxation in the Rotating Frame Induced by Chemical Exchange, S. Michaeli, D.J. Sorce, D. Idiyatullin, K. Ugurbil, and M. Garwood, J. Magn. Reson. 169, 293-299, 2004.

Predicting Response to Neoadjuvant Chemotherapy of Locally Advanced Breast Cancer with In Vivo 1H MRS: A Pilot Study at 4 Tesla, S. Meisamy, P.J. Bolan, E.H. Baker, R.L. Bliss, E. Gulbahce, L.I. Everson, M.T. Nelson, T.H. Emory, T.M. Tuttle, D. Yee, and M. Garwood, Radiology, 233, 424-431, 2004.

In Vivo Visualization of Alzheimer.s Amyloid Plaques by MRI in Transgenic Mice Without a Contrast Agent, C.R. Jack, M. Garwood, T.M. Wengenack, B. Borowski, G.L. Curran, J. Lin, G. Adriany, O.H.J. Grö R. Grimm, and J.F. Poduslo, Magn. Reson. Med. 52, 1263-1271, 2004.

Adding in Vivo Quantitative 1H MR Spectroscopy to Improve Diagnostic Accuracy of Breast MR Imaging: Preliminary Results of Observer Performance Study at 4.0 T, S. Meisamy, P.J. Bolan, E.H. Baker, M.G. Pollema, C.T. Le, F. Kelcz, M.C. Lechner, B.A. Luikens, R.A. Carlson, K.R. Brandt, K.K. Amrami, M.T. Nelson, L.I. Everson, T.H. Emory, T.M. Tuttle, D. Yee, and M. Garwood, Radiology 236, 465-475, 2005.

Uncovering Hidden In Vivo Resonances Using Editing Based on Localized TOCSY, M. Marjanska, P.-G. Henry, P.J. Bolan, B. Vaughan, E.R. Seaquist, R. Gruetter, K. Ugurbil, and M. Garwood, Magn. Reson. Med. 53, 783-789, 2005.

Exchange-Influenced T2. Contrast in Human Brain Images Measured by Adiabatic RF Pulses, S. Michaeli, H.I. Grö O.H.J. Grö D.J. Sorce, R.A. Kauppinen, C.S. Springer, Jr., K. Ugurbil, and M. Garwood, Magn. Reson. Med. 53, 823-829, 2005.

Monitoring Disease Progression in Transgenic Mouse Models of Alzheimer.s Disease with Proton Magnetic Resonance Spectroscopy, M. Marjanska, G.L. Curran, T.M. Wengenack, P.-G. Henry, R.L. Bliss, J.F. Poduslo, C.R. Jack, Jr., K. Ugurbil, and M. Garwood, Proc. Natl. Acad. Sci. USA 102, 11906-11910, 2005.

Fast and Quiet MRI Using a Swept Radiofrequency, D. Idiyatullin, C. Corum, J.-Y. Park, and M. Garwood, J. Magn. Reson. 181, 342-349, 2006.

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