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Dr. Gülin Öz is an associate professor in the Department of Radiology who specializes in magnetic resonance spectroscopy (MRS). Dr. Oz graduated from Bosphorus University in Istanbul, Turkey with BS degrees in Physics and Chemistry and obtained her PhD in Biochemistry at the University of Minnesota. She continued with postdoctoral training at the Center for Magnetic Resonance Research (CMRR) where she joined the faculty as assistant professor in 2006. Here she also served as the MR Core Director of the General Clinical Research Center (GCRC) from 2005-2009.
- To develop high and ultrahigh field MRS methodology for human and rodent applications.
- To establish in vivo 1H MRS biomarkers of neurodegeneration, in parallel studies with patients and transgenic mouse models, with particular emphasis on movement disorders such as spinocerebellar ataxias and Parkinson’s disease. Such biomarkers are expected to facilitate early disease detection and treatment monitoring in pre-clinical and clinical trials.
- To determine the effects of diabetes and the hypoglycemic consequences of intensive insulin therapy on brain glucose and glycogen metabolism in humans and to elucidate pathogenic mechanisms of hypoglycemia unawareness syndrome using 1H and 13C MRS.
Selected Recent Publications:
Emir UE, Tuite PJ, Öz G (2012) Elevated pontine and putamenal GABA levels in mild-moderate Parkinson disease detected by 7 tesla ¹H MRS, PLoS One, 7(1): e30918. doi:10.1371/journal.pone.0030918.
Emir UE, Auerbach EJ, Van De Moortele PF, Marjańska M, Ugurbil K, Terpstra M, Tkáč I, Öz G (2012) Regional neurochemical profiles in the human brain measured by 1H MRS at 7 tesla using local B1 shimming, NMR Biomed, 25: 152–160.
Öz G, Tesfaye N, Kumar A, Deelchand DK, Eberly LE, Seaquist ER (2012) Brain Glycogen Content and Metabolism in Subjects with Type 1 Diabetes and Hypoglycemia Unawareness, J Cereb Blood Flow Metab, 32(2): 256-63.
Öz G, Vollmers ML, Nelson CD, Shanley R, Eberly LE, Orr HT, Clark HB (2011) In vivo Monitoring of Recovery from Neurodegeneration in Conditional Transgenic SCA1 Mice, Exp Neurology, 232(2):290-8.
Öz G, Tkáč I (2011) Short-echo, single-shot, full-intensity 1H MRS for neurochemical profiling at 4T: Validation in the cerebellum and brainstem, Magn Reson Med, 65(4):901-10.
Öz G, Iltis I, Hutter D, Thomas W, Bushara KO, Gomez CM (2011) Distinct Neurochemical Profiles of Spinocerebellar Ataxias 1, 2, 6 and Cerebellar Multiple System Atrophy, Cerebellum, 10(2):208-17.
Öz G, Nelson CD, Koski DM, Henry PG, Marjańska M, Deelchand DK, Shanley R, Eberly LE, Orr HT, Clark HB (2010) Noninvasive Detection of Pre-symptomatic and Progressive Neurodegeneration in a Mouse Model of Spinocerebellar Ataxia type 1, J Neurosci, 30:3831-3838.
Öz G, Hutter D, Tkáč I, Clark HB, Gross MD, Jiang H, Eberly LE, Bushara KO, Gomez CM (2010) Neurochemical Alterations in Spinocerebellar Ataxia Type 1 and their Correlations with Clinical Status, Mov Disord, 25:1253–1261.
Iltis I, Hutter D, Bushara KO, Clark HB, Gross MD, Eberly LE, Gomez CM, Öz G (2010) 1H MR Spectroscopy in Friedreich’s Ataxia and Ataxia with Oculomotor Apraxia Type 2 Brain Res, 1358:200-210.
Öz G, Kumar A, Rao JP, Kodl CT, Chow L, Eberly LE, Seaquist ER (2009) Human Brain Glycogen Metabolism during and following Hypoglycemia, Diabetes, 58(9):1978-85.
Tkáč I, Öz G, Adriany G, Uğurbil K, Gruetter R (2009) In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T, Magn Reson Med, 62:868–879.
Öz G, Seaquist ER, Kumar A, Criego A, Benedict LE, Rao JP, Henry PG, van de Moortele PF, Gruetter R (2007) Human Brain Glycogen Content and Metabolism: Implications on its Role in Brain Energy Metabolism, Am J Physiol Endocrinol Metab, 292(3): E946-51.