Faculty and Staff

Pierre-Gilles Henry

Assistant Professor
612-284-7330

henry [at] cmrr (dot) umn (dot) edu

Education:
1995	M.S., Electrical Engineering, SUPELEC, Paris, France
1997	M.S., Neuroscience, University Paris VI, Paris, France
2000	Ph.D., Neuroscience, CEA-SHFJ, Orsay, France
2001-2002	Postdoctoral Associate, CMRR, University of Minnesota
2002-2006	Assistant Professor, Research-Track, CMRR, University of Minnesota
2006-	Assistant Professor, Tenure-Track, CMRR, University of Minnesota

Research Interests:

My group focuses on using Magnetic Resonance Spectroscopy (MRS) to understand brain function at the biochemical and cellular level, and to identify new biomarkers of brain disorders. Current research topics include:

To understand how neurons and astrocytes cooperate metabolically to support neurotransmission. For this purpose, we perform tracer studies using 13C-labeled substrates and 13C MRS, which allows us to measure metabolic rates non-invasively in the brain in both neurons and astrocytes.
To develop new metabolic models to analyze 13C MRS data, particularly two-compartment neuronal-glial models to measure the "glutamate-glutamine cycle". This would provide a non-invasive measurement of glutamatergic neurotransmission.
To explore the potential of hyperpolarized 13C for the study of brain metabolism and for the detection of tumors in brain and other tissues.
To develop new methodologies for 1H MRS and 1H MRSI at very high-field for the measurement of metabolite concentrations ("neurochemical profile") with improved spatial and temporal resolution.

Society Memberships:

International Society of Magnetic Resonance in Medicine
International Society of Neurochemistry

Selected publications:

Henry P-G, Tkac I, Gruetter R: 1H-localized broadband 13C NMR spectroscopy of the rat brain in vivo at 9.4 Tesla. Magn Reson Med 2003; 50:684-692
Henry P-G, Oz G, Provencher S, Gruetter R: Toward Dynamic isotopomer analysis in the rat brain in vivo: Automatic quantitation of 13C NMR spectra using LCModel. NMR Biomed 2003; 16:400-412
Deelchand D, Ugurbil K, Henry P-G. Investigating Brain Metabolism at High Fields using Localized 13C NMR Spectroscopy without 1H Decoupling. Magn Reson Med 2006; 55(2):279-286
Henry P-G, Marjanska M, Walls JD, Valette J, Gruetter R, Ugurbil K. POCE NMR Spectroscopy in Strongly Coupled Second Order Spin Systems. Magn Reson Med 2006; 55(2):250-257
Henry P-G, Adriany G, Deelchand DK, Gruetter R, Marjanska M, Oz G, Seaquist ER, Shestov A, Ugurbil K: In vivo 13C NMR Spectroscopy and Metabolic Modeling in the Brain: A Practical Perspective. Magn Reson Imag 2006; 24(4):527-539
Shestov AA, Valette J, Ugurbil K, Henry PG. On the Reliability of 13C Metabolic Modeling with Two-Compartment Neuronal-Glial Models. J Neurosci Res 2007; Epub ahead of print.
Henry PG, Russeth KP, Tkac I, Drewes LR, Andrews MT, Gruetter R. Brain energy metabolism and neurotransmission at near-freezing temperatures: in vivo 1H MRS study of a hibernating mammal. J. Neurochem 2007; 101(6):1505-1515
Valette J, Park JY, Gröhn O, Ugurbil K, Garwood M, Henry PG. Spectroscopic imaging with volume selection by unpaired adiabatic p pulses: theory and application. J Magn Reson 2007; in press

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