Multi-Band Accelerated EPI Pulse Sequences

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The multi-band accelerated EPI sequences developed at CMRR are now available for use at other institutions on compatible Siemens scanners by C2P agreement with CMRR and Siemens.

These sequences and the accompanying reconstructions are being actively developed as key components of the Human Connectome Project.

Gallery of example images & protocols

The available sequence variants and supported software versions are listed below. If you are interested in obtaining these sequences, the CMRR C2P instructions and agreement can be found on the web page of the University of Minnesota Office for Technology Commercialization. Once you have executed a C2P agreement and have been given an access password, the sequence binaries can be downloaded here by selecting the desired release number.

Note to users: If you have noticed a bug or have a request for a new feature in a future release, please open a new support request. Be sure to include the sequence version number (e.g. VB17A R006a), sequence variant (e.g. BOLD, diffusion), and the model of scanner you are using in the problem description.

Security concerns: The sequences and software are developed in a firewalled environment, the web server is regularly checked for network vulnerabilities, and the downloadable files here are regularly scanned for viruses. To detect unexpected changes, the downloads available here are regularly checked remotely against baseline checksums stored on the remote machine. Also, Siemens provides virus software for their scanners. You can confirm that you have downloaded a valid version correctly by comparing a md5sum of the downloaded file with these checksums.

Download Multi-Band EPI 2D BOLD/SE/DIFF Sequences:

Release R012b
Released 18 May 2015
Expires 1 January 2016

Release Notes R012b
Release R012b for VB17A (build 8-Jul-2015)
Release R012b for VB17A-Step2.1/F15 (8Tx) (build 18-May-2015)
Release R012b for VB17A-Step2.3/F37 (8Tx/16Tx F37-F40) (build 2-Jul-2015)
Release R012b for VB19A (build 18-May-2015)
Release R012b for VB20P (build 18-May-2015)
Release R012b for VD11D (build 18-May-2015)
Release R012b for VD13A (SP4 or newer) (build 18-May-2015)
Release R012b for VD13B (build 18-May-2015)
Release R012b for VD13C-SP2 (build 18-May-2015)
Release R012b for VD13D (build 18-May-2015)

Release R012b_MRIR++
NOTE: This is a special release intended only for UHF VB17A systems that have been upgraded with my "MRIR++" image reconstruction computer. It enables GPU acceleration for image reconstruction under VB17A. (GPU acceleration using Siemens-supported hardware is available for Tim4G platforms in the standard VD13x releases.)
Released 18 May 2015
Expires 1 January 2016

Release Notes R012b
Release R012b for VB17A (build 18-May-2015)
Release R012b for VB17A-Step2.1/F15 (8Tx) (build 18-May-2015)
Release R012b for VB17A-Step2.3/F37 (8Tx/16Tx F37-F40) (build 2-Jul-2015)

Release HCP_v1
NOTE: This version is only provided for continuity for ongoing longitudinal studies started in 2012 or earlier. It has significant known issues. For new studies it is highly recommended to use the most current version. No further updates will be provided for this version.
Released 10 February 2014
Expires 1 March 2016

Release Notes HCP_v1
Release HCP_v1 for VB17A (build 3-Mar-2014)
Release HCP_v1 for VD11D (build 10-Feb-2014)

Download Multi-Band EPI Remote Reconstruction Server:

An optional remote reconstruction server is available which allows for the possibility of dramatically improving the image reconstruction speed for demanding studies.

This is currently only available by special request.

A description of the setup with sample timing results is available.

Release R007
Updated to support sequence versions R012 and newer. Now includes drivers for Intel 10 GbE cards and install instructions for VD/VE-line systems.
Released 19 December 2014
Release R007 for Linux x86-64

Release R006
Major update, adds optional CUDA GPU support. Fully compatible with sequence versions R011a and older; will mostly still work with sequences R012 and newer but does not support any new features added in those versions (may crash or fail silently).
Released 3 May 2013
Release R006a for Linux x86-64


  1. Moeller S, Yacoub E, Olman CA, Auerbach E, Strupp J, Harel N, Uğurbil K. Multiband multislice GE-EPI at 7 tesla, with 16-fold acceleration using partial parallel imaging with application to high spatial and temporal whole-brain fMRI. Magn Reson Med. 2010;63(5):1144-1153. [PubMed]

  2. Setsompop K, Gagoski BA, Polimeni JR, Witzel T, Wedeen VJ, Wald LL. Blipped-controlled aliasing in parallel imaging for simultaneous multislice echo planar imaging with reduced g-factor penalty. Magn Reson Med. 2012;67(5):1210-1224. [PubMed]

  3. Xu J, Moeller S, Auerbach EJ, Strupp J, Smith SM, Feinberg DA, Yacoub E, Uğurbil K. Evaluation of slice accelerations using multiband echo planar imaging at 3 T. Neuroimage. 2013;83(0):991-1001. [PubMed]

  4. Auerbach EJ, Xu J, Yacoub E, Moeller S, Uğurbil K. Multiband accelerated spin-echo echo planar imaging with reduced peak RF power using time-shifted RF pulses. Magn Reson Med. 2013;69:1261-1267. [PubMed]

  5. Sotiropoulos SN, Moeller S, Jbabdi S, Xu J, Andersson JL, Auerbach EJ, Yacoub E, Feinberg D, Setsompop K, Wald LL, Behrens TEJ, Uğurbil K, Lenglet C. Effects of image reconstruction on fiber orientation mapping from multichannel diffusion MRI: Reducing the noise floor using SENSE. Magn Reson Med. 2013;70(6):1682-1689. [PubMed]

  6. Cauley SF, Polimeni JR, Bhat H, Wald LL, Setsompop K. Interslice leakage artifact reduction technique for simultaneous multislice acquisitions. Magn Reson Med. 2014 Jul;72(1):93-102. [PubMed]

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