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Casey Johnson, PhD
I am developing new MRI methods for musculoskeletal applications, with a particular emphasis on the hip joint. These developments include in vivo imaging at 3T and 7T and ex vivo imaging at 9.4T. I am investigating a number of new sequences to perform comprehensive imaging of the pediatric and young adult hip, including detection of early cartilage and bone damage that may lead to osteoarthritis. I am also involved in projects focusing on the knee, spine, and shoulder. This work is done in collaboration with investigators at CMRR as well as colleagues in veterinary medicine, orthopaedic surgery, physical therapy, and engineering. Prior to joining CMRR in July 2015, I had developed MRI techniques for time-resolved contrast-enhanced MR angiography (Mayo Clinic) and psychiatric neuroimaging (University of Iowa).
- Quantitative mapping of MR relaxation times as an early marker of disease
- Acceleration techniques for high spatial and temporal resolution
- Efficient methods for 3D imaging
- Ultrahigh field (7T+) techniques and applications
Johnson CP, Van de Moortele PF, Wang L, Ugurbil K, Ellermann JM. Chapter 24: Ultrahigh-field whole-body MRI for cartilage imaging: technical challenges. Biophysics and Biochemistry of Cartilage by NMR and MRI. Eds: Xia Y, Momot K. The Royal Society of Chemistry, Cambridge, UK 2016.
Ellermann J, Johnson CP, Wang L, Macalena J, Nelson B, LaPrade RR. New insights into the epiphyseal cartilage origin and subsequent osseous manifestation of juvenile osteochondritis dissecans utilizing a modified clinical MRI protocol. Radiology 2016.
Wang L, Nissi MJ, Toth F, Johnson CP, Garwood M, Carlson CS, Ellermann J. Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans. Magn Reson Med 2016.
Wang L, Nissi MJ, Toth F, Shaver J, Johnson CP, Zhang J, Garwood M, Carlson CS, Ellermann J. Multiparametric MRI of epiphyseal cartilage necrosis (osteochondrosis) with histological validation in a goat model. PLoS One 2015; 10(10):e0140400.
Bhave S, Lingala SG, Johnson CP, Magnotta VA, Jacob M. Accelerated whole brain multi-parameter mapping using blind compressed sensing. Magn Reson Med 2016; 75(3):1175-86.
Wassef SN, Wemmie JA, Johnson CP, Johnson H, Paulsen JS, Long JD, Magnotta VA. T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression. Mov Disord 2015; 30(8):1107-1114.
Johnson CP, Folmer RL, Oguz I, Warren L, Christensen GE, Fiedorowicz JG, Magnotta VA, Wemmie JA. Brain abnormalities in bipolar disorder detected by quantitative T1ρ mapping. Mol Psychiatry 2015; 20(2):201-206.
Johnson CP, Thedens DR, Magnotta VA. Precision-guided sampling schedules for efficient T1ρ mapping. J Magn Reson Imaging 2015; 41(1):242-250.
Johnson CP, Heo HY, Thedens DR, Wemmie JA, Magnotta VA. Rapid acquisition strategy for functional T1ρ imaging of the brain. Magn Reson Imaging 2014; 32(9):1067-1164.
Johnson CP, Weavers PT, Borisch EA, Grimm RC, Hulshizer RC, LaPlante CC, Rossman PJ, Glockner JF, Young PM, Riederer SJ. Three-station three-dimensional bolus-chase MR angiography with real-time fluoroscopic tracking. Radiology 2014; 272(1):241-251.
Magnotta VA, Johnson CP, Folmer RL, Wemmie JA. Functional T1ρ imaging in panic disorder. Biol Psychiatry 2014; 75(11):884-891.
Weavers PT, Borisch EA, Johnson CP, Riederer SJ. Acceleration apportionment: a method of improved 2D SENSE acceleration applied to 3D contrast-enhanced MR angiography. Magn Reson Med 2014; 71(2):672-680.
Johnson CP, Polley TW, Glockner JF, Young PM, Riederer SJ. Buildup of image quality in view-shared time-resolved 3D CE-MRA. Magn Reson Med 2013; 70(2):348-357.
Johnson CP, Borisch EA, Glockner JF, Young PM, Riederer SJ. Time-resolved dual-station calf-foot three-dimensional bolus chase MR angiography with fluoroscopic tracking. J Magn Reson Imaging 2012; 36(5):1168-1178.
Johnson CP, Haider CR, Borisch EA, Glockner JF, Riederer SJ. Time-resolved bolus-chase MR angiography with real-time triggering of table motion. Magn Reson Med 2010; 64(3):629-637.