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Casey P. Johnson, PhD
I am developing new MRI methods for a variety of applications with a particular emphasis on bone and joint disorders. These developments include in vivo imaging at 3T and 7T and ex vivo imaging at 9.4T. My primary project focuses on development of quantitative imaging techniniques to detect early bone and cartilage damage that may lead to osteoarthritis. I am also involved in projects focusing on the knee, spine, and bone tumors, and I have broad interest in other application areas such as neurological and psychiatric disorders, vascular disease, and comparative medicine. This work is done in collaboration with investigators at CMRR as well as colleagues in veterinary medicine, orthopaedic surgery, rehabilitation medicine, and engineering.
- Quantitative mapping of MR relaxation times as an early marker of disease
- Efficient and accelerated methods for highly-resolved 3D imaging
- Ultrahigh field (7T+) techniques and applications
- Comparative medicine
Johnson CP, Wang L, Tóth F, Aruwajoye O, Kirkham B, Carlson CS, Kim HK, Ellermann JM. Quantitative susceptibility mapping detects neovascularization of the epiphyseal cartilage after ischemic injury in a piglet model of Legg-Calvé-Perthes disease. J Magn Reson Imaging 2018. [PubMed]
Johnson CP, Wang L, Tóth F, Aruwajoye O, Carlson CS, Kim HK, Ellermann JM. Quantitative MRI helps to detect hip ischemia: preclinical model of Legg-Calvé-Perthes disease. Radiology 2018; 289(2):386-395. [PubMed]
Ellermann J, Johnson CP, Wang L, Macalena JA, Nelson BJ, LaPrade RF. Insights into the epiphyseal cartilage origin and subsequent osseous manifestation of juvenile osteochondritis dissecans with a modified clinical MR imaging protocol: a pilot study. Radiology 2017; 282(3):798-806. [PubMed]
Johnson CP, Van de Moortele PF, Wang L, Ugurbil K, Ellermann JM. Chapter 24: Ultrahigh-field whole-body MRI for cartilage imaging: technical challenges. Biophysics and Biochemistry of Cartilage by NMR and MRI. Eds: Xia Y, Momot K. The Royal Society of Chemistry, Cambridge, UK 2016, 671-705.
Johnson CP, Folmer RL, Oguz I, Warren L, Christensen GE, Fiedorowicz JG, Magnotta VA, Wemmie JA. Brain abnormalities in bipolar disorder detected by quantitative T1ρ mapping. Mol Psychiatry 2015; 20(2):201-206. [PubMed]
Johnson CP, Weavers PT, Borisch EA, Grimm RC, Hulshizer RC, LaPlante CC, Rossman PJ, Glockner JF, Young PM, Riederer SJ. Three-station three-dimensional bolus-chase MR angiography with real-time fluoroscopic tracking. Radiology 2014; 272(1):241-251. [PubMed]