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Małgorzata Marjańska, Ph.D.
Małgorzata (Gosia) Marjańska is a professor in the Department of Radiology. Dr. Marjańska received a B.S. in chemistry with minor in mathematics from Loyola University of Chicago and a Ph.D. in chemistry from the University of California at Berkeley. She joined the Center for Magnetic Resonance Research (CMRR) in 2002 as a post-doctoral fellow working with Prof. Kamil Ugurbil and subsequently became a research assistant professor two years later, and an assistant professor in 2013. In 2015, she was promoted to an associate professor and in 2020 to a professor.
Dr. Marjańska first encountered magnetic resonance while working with Prof. Keith Jameson at Loyola University of Chicago, first learning and then training other undergraduates to operate a 300 MHz Varian system. During the summer after her 3rd year of undergraduate studies, she worked at Bell Laboratories with Dr. Peter Mirau on solid state NMR characterization of polymer films. In order to follow her interest in NMR, she decided to pursue a Ph.D. at the University of California at Berkeley in the group of Prof. Alexander Pines. Her thesis titled “Quantum Logic Gates, Local Field, Selective Excitation and Structural Studies of Dipolar Couplings in Oriented Molecules” was focused on NMR as a technique to study molecules dissolved in liquid crystals.
In her work at the CMRR, Dr. Marjańska is interested in:
- 1H spectroscopy in humans (brain and other parts of the body) and rodents including development of spectroscopy techniques over a wide range of field strengths (3 T up to 16.4 T), quantification approaches and methods, and applications of spectroscopy to aging and various diseases such as Alzheimer's disease, dystonia, depression, and brain tumors
- development and assessment of robust, non-invasive, and repeatable MRI methods for discovery of quantitative biomarkers for clinical research and practice
- T2 relaxation of neurochemicals at different field strengths (4 T and 7 T)
- characterization of animal models of Alzheimer's disease using magnetic resonance in order to search for biomarkers that have the potential to be used in humans
- evaluation of magnetic resonance as outcome measures for detecting disease modification
- hyperpolarization of 13C labeled probes for the study of brain metabolism and function
- imaging of contrast agents.
- Branzoli F, Deelchand DK, Sanson M, Lehéricy S, Marjanska M. In vivo 1H MRS detection of cystathionine in human brain tumors. Magnetic Resonance in Medicine. 2019; doi: 10.1002/mrm.27810.
- Branzoli F, Pontoizeau C, Tchara L, Di Stefano AL, Kamoun A, Deelchand DK, Valabrègue R, Lehéricy S, Sanson M, Ottolenghi C, Marjanska M. Cystathionine as a marker for 1p/19q codeleted gliomas by in vivo magnetic resonance spectroscopy. Neuro-Oncology. 2019;21:765.
- Marjanska M, McCarten JR, Hodges JS, Hemmy LS, Terpstra M. Distinctive neurochemistry in Alzheimer’s disease via 7 T in vivo magnetic resonance spectroscopy. Journal of Alzheimer’s Disease. 2019;68:559.
- Marjanska M, Deelchand DK, Hodges JS, McCarten JR, Hemmy LS, Grant A, Terpstra M. Altered macromolecular pattern and content in the aging human brain. NMR in Biomedicine 2018;31:e3865.
- Marjańska M, Shestov AA, Deelchand DK, Kittelson E, Henry PG. Brain metabolism under different anesthetic conditions using hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate. NMR in Biomedicine. 2018;31:e4012.
- Penheiter AR, Deelchand DK, Kittelson E, Damgard SE, Murphy SJ, O’Brien DR, Bamlet WR, Passow MR, Smyrk TC, Couch FJ, Vasmatzis G, Port JD, Marjanska M, Carlson SK. Identification of pyruvate-lactate signature in pancreatic intraductal papillary mucinous neoplasms. Pancreatology 2018;18:46.
- Branzoli F, Di Stefano AL, Capelle L, Ottolenghi C, Valabrègue R, Deelchand DK, Bielle F, Villa C, Baussart B, Lehéricy S, Sanson M, Marjanska M. Highly specific determination of IDH status using edited in vivo magnetic resonance spectroscopy. Neuro-Oncology 2017; doi: 10.1093/neuron/nox214.
- Deelchand DK, Auerbach EJ, Marjanska M. Apparent diffusion coefficients of the five major metabolites measured in the human brain in vivo at 3 T. Magnetic Resonance in Medicine 2018;79:2896-2901.
- Deelchand DK, Auerbach EJ, Kobayashi N, Marjanska M. Transverse relaxation time constants of the five major metabolites in human brain measured in vivo using LASER and PRESS at 3 T. Magnetic Resonance in Medicine 2018;79:1260.
- Marjanska M, McCarten JR, Hodges J, Hemmy LS, Grant A, Deelchand DK, Terpstra M. Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using 1H magnetic resonance spectroscopy at 7 T. Neuroscience 2017;354:168-177.
- Cheong I, Marjanska M, Deelchand DK, Eberly LE, Walk D, Oz G. Ultra-high field proton MR spectroscopy in early-stage amyotrophic lateral sclerosis. Neurochemical Research 2017;42:1845.
- Srivastava K, Weitz EA, Peterson KL, Marjanska M, Pierre VC. Fe- and Ln-DOTAm-F12 are effective paramagnetic fluorine contrast agents for MRI in water and blood. Inorganic Chemistry 2017;56:1546.
- Deelchand DK, Marjanska M, Hodges J, Terpstra M. Sensitivity and specificity of human brain glutathione concentrations measured using short echo time 1H MRS at 7 T. NMR in Biomedicine 2016;29:600.
- Andronesi OC, Loebel F, Bogner W, Marjanska M, Vander Heiden MG, Iafrate AJ, Dietrich J, Batchelore TT, Gerstner ER, Kaelin Jr. WG, Chi AS, Rosen BR, Cahill DP. Treatment response assessment in IDH-mutant glioma patients by non-invasive 3D functional spectroscopic mapping of 2-hydroxyglutarate. Clinical Cancer Research 2016;22:1632.
- NAllaïli N, Valabrègue R, Auerbach EJ, Guillemot V, Yahia-Cherif L, Bardinet E, Jabourian M, Fossati P, Lehéricy S, Marjańska M. Single voxel 1H spectroscopy in the human hippocampus at 3 T using the LASER sequence: characterization of neurochemical profile and reproducibility. NMR in Biomedicine 2015;28:1209-1217.
- Powell N, Park J-Y, Valette J, Garwood M, Marjanska M. Gradient rotating outer volume excitation (GROOVE): A novel method for single-shot 2-D OVS. Magnetic Resonance in Medicine 2015;73:139-149.
- Deelchand DK, Henry P-G, Marjanska M. Effect of Carr-Purcell refocusing pulse trains on transverse relaxation times of metabolites in rat brain at 9.4 T. Magnetic Resonance in Medicine 2015;73:13-20.
- Tremblay S, Beaulè V, Proulx S, Lafleur L-P, Doyon J, Marjanska M, Thèoret H. The use of magnetic resonance spectroscopy as a tool for the measurement of bi-hemispheric transcranial electric simulation effects on primary motor cortex metabolism. Journal of Visualized Experiments 2014, e51631, doi: 10.3791/51361.
- Marjanska M, Uzay EE, Deelchand DK, Terpstra M. Faster metabolite 1H transverse relaxation in the elder human brain. PLoS One 2013;8:e77572.
- Marjańska M, Lehéricy S, Valabrègue R, Popa T, Worbe Y, Russo M, Auerbach EJ, Grabli D, Bonnet C, Gallea C, Coudert M, Yahia-Cherif L, Vidailhet M, Meunier C. Brain dynamic neurochemical changes in dystonic patients: A magnetic resonance spectroscopy study. Movement Disorders 2013;28:201-209.
- Marjańska M, Eberly LE, Adriany G, Verdoliva SN, Garwood M, Chow L. Influence of foot orientation on the appearance and quantification of 1H magnetic resonance muscle spectra obtained from the soleus and the vastus lateralis. Magnetic Resonance in Medicine 2012;68:1731-1737.
- Marjańska M, Auerbach EJ, Valabrègue R, Van de Moortele P-F, Adriany G, Garwood M. Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7 T: T2 relaxation times and concentrations of cerebral metabolites. NMR in Biomedicine 2012;25:332- 339.
- Marjanska M, Iltis I, Shestov AA, Deelchand DK, Nelson C, Ugurbil K, Henry P-G. In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate. Journal of Magnetic Resonance 2010;206:210-218.
- Marjanska M, Curran GL, Wengenack TM, Henry P-G, Bliss RL, Poduslo JF, Jack CR, Ugurbil K, Garwood M. Monitoring disease progression in transgenic mouse models of Alzheimer’s disease with proton magnetic resonance spectroscopy. Proceedings of National Academy of Sciences of the United States of America 2005;102:11906-11910.