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Gülin Öz


2-126 CMRR


Dr. Gülin Öz is a professor in the Department of Radiology who specializes in magnetic resonance spectroscopy (MRS). She graduated from Bosphorus University in Istanbul, Turkey, with BS degrees in Physics and Chemistry and obtained her PhD in Biochemistry at the University of Minnesota. She continued with postdoctoral training at the Center for Magnetic Resonance Research (CMRR) where she joined the faculty as assistant professor in 2006.

Dr. Öz uses high field, multi-nuclear MRS to delineate neurochemical and metabolic alterations in neurodegenerative diseases and diabetes. She leads a program in spinocerebellar ataxias and has studied neurochemistry in Parkinson’s, Huntington’s, Alzheimer’s diseases and ALS. She co-led an effort by the MRS Consensus Group to provide guidelines for MRS data acquisition and analysis, quality assessment, and interpretation. She leads a multi-site Bioengineering Research Partnership (BRP) for across-platform harmonization of advanced MRS methods. Finally, she serves as MPI in the READISCA study, an international clinical trial readiness initiative in spinocerebellar ataxias. The goal of the imaging effort in READISCA is to validate MRI and MRS biomarkers in the earliest stages of neurodegeneration.

Research Interests:

  • To develop high and ultrahigh field MRS methodology for human and rodent applications.
  • To establish in vivo 1H MRS biomarkers of neurodegeneration, in parallel studies with patients and transgenic mouse models, with particular emphasis on movement disorders such as spinocerebellar ataxias and Parkinson’s disease. Such biomarkers are expected to facilitate early disease detection and treatment monitoring in pre-clinical and clinical trials.
  • To determine the effects of diabetes and the hypoglycemic consequences of intensive insulin therapy on brain glucose and glycogen metabolism in humans and to elucidate pathogenic mechanisms of hypoglycemia unawareness syndrome using 1H and 13C MRS.

Selected Publications:

Deelchand DK, Joers JM, Ravishankar A, Lyu T, Emir UE, Hutter D, Gomez CM, Bushara KO, Lenglet C, Eberly LE, Öz G (2019) Sensitivity of MRI volumetry and MRS to progression of spinocerebellar ataxia type 1, Mov Disord Clin Pract, 6(7):549-558.

Cheong I, Deelchand DK, Eberly LE, Marjańska M, Manousakis M, Guliani G, Walk D, Öz G (2019) Neurochemical Correlates of Functional Decline in Amyotrophic Lateral Sclerosis, J Neurol Neurosurg Psychiatry, 90(3):294-301.

Joers JM, Deelchand DK, LyuT, EmirUE, Hutter D, GomezCM, BusharaKO, Eberly LE, Öz G (2018) Neurochemical abnormalities in premanifest and early spinocerebellar ataxias, Ann Neurol, 83(4):816-829.

Park YW, Deelchand DK, Joers JM, Hanna B, Kantarci K, Soher BJ, Barker PB, Park HW, Öz G, Lenglet C (2018) AutoVOI: Real-time automatic prescription of volume-of-interest for single voxel spectroscopy, Magn Reson Med, 80(5):1787-1798.

Deelchand DK, Kantarci K, Öz G. (2018) Improved localization, spectral quality and repeatability with advanced MRS methodology in the clinical setting, Magn Reson Med, 79(3):1241-1250.

Seaquist ER, Moheet A, Kumar A, Deelchand DK, Terpstra M, Kubisiak K, Eberly LE, Henry PG, Joers JM, Öz G (2017) Hypothalamic Glucose Transport in Humans during Experimentally Induced Hypoglycemia Associated Autonomic Failure, J Clin Endocrinol Metab, 102(9):3571-3580.

Öz G, DiNuzzo M, Kumar A, Moheet A, Khowaja A, Kubisiak K, Eberly LE, Seaquist ER (2017) Cerebral Glycogen in Humans following Acute and Recurrent Hypoglycemia: Implications on a Role in Hypoglycemia Unawareness, J Cereb Blood Flow Metab, 37(8):2883-2893.

Terpstra M, Cheong I, Lyu T, Deelchand DK, Emir UE, Bednařík P, Eberly LE, Öz G (2016) Test-retest reproducibility of neurochemical profiles with short-echo, single-voxel MR spectroscopy at 3T and 7T, Magn Reson Med, 76:1083–91.

Öz G, Kittelson E, Demirgöz D, Rainwater O, Eberly LE, Orr HT, Clark HB (2015) Assessing Recovery from Neurodegeneration in Spinocerebellar Ataxia 1: Comparison of in vivo Magnetic Resonance Spectroscopy with Motor Testing, Gene Expression and Histology, Neurobiol Dis, 74: 158-166.

Deelchand DK, Adanyeguh IM, Emir UE, Nguyen TM, Valabregue R, Henry PG, Mochel F, Öz G (2015) Two-site reproducibility of cerebellar and brainstem neurochemical profiles with short-echo, single voxel MRS at 3T, Magn Reson Med, 73: 1718-25.

Öz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Dincer A, Dydak U, Emir UE, Frahm J, González RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hüppi PS, Hurd RE, Kantarci K, Klomp DWJ, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjańska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJW, Ratai EM, Ross BD, Scheenen TWJ, Schuster C, Smith ICP, Soher BJ, Tkáč I, Vigneron DB, Kauppinen RA. The MRS Consensus Group. (2014) Clinical Proton MR Spectroscopy in Central Nervous System Disorders, Radiology, 270(3):658-79.

Emir UE, Auerbach EJ, Van De Moortele PF, Marjańska M, Ugurbil K, Terpstra M, Tkáč I, Öz G (2012) Regional neurochemical profiles in the human brain measured by 1H MRS at 7 tesla using local B1 shimming, NMR Biomed, 25: 152–160.

Öz G, Tkáč I (2011) Short-echo, single-shot, full-intensity 1H MRS for neurochemical profiling at 4T: Validation in the cerebellum and brainstem, Magn Reson Med, 65(4):901-10.

Öz G, Nelson CD, Koski DM, Henry PG, Marjańska M, Deelchand DK, Shanley R, Eberly LE, Orr HT, Clark HB (2010) Noninvasive Detection of Pre-symptomatic and Progressive Neurodegeneration in a Mouse Model of Spinocerebellar Ataxia type 1, J Neurosci, 30:3831-3838.

Öz G, Kumar A, Rao JP, Kodl CT, Chow L, Eberly LE, Seaquist ER (2009) Human Brain Glycogen Metabolism during and following Hypoglycemia, Diabetes, 58(9):1978-85.

Tkáč I, Öz G, Adriany G, Uğurbil K, Gruetter R (2009) In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T, Magn Reson Med, 62:868–879.

Öz G, Seaquist ER, Kumar A, Criego A, Benedict LE, Rao JP, Henry PG, van de Moortele PF, Gruetter R (2007) Human Brain Glycogen Content and Metabolism: Implications on its Role in Brain Energy Metabolism, Am J Physiol Endocrinol Metab, 292(3): E946-51.