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Pierre-Gilles Henry

Assistant Professor


1995 M.S., Electrical Engineering, SUPELEC, Paris, France
1997 M.S., Neuroscience, University Paris VI, Paris, France
2000 Ph.D., Neuroscience, CEA-SHFJ, Orsay, France
2001-2002 Postdoctoral Associate, CMRR, University of Minnesota
2002-2006 Assistant Professor, Research-Track, CMRR, University of Minnesota
2006- Assistant Professor, Tenure-Track, CMRR, University of Minnesota

Research Interests:

  • To understand how neurons and astrocytes cooperate metabolically to support neurotransmission. For this purpose, we perform tracer studies using 13C-labeled substrates and 13C MRS, which allows us to measure metabolic rates non-invasively in the brain in both neurons and astrocytes.
  • To develop new metabolic models to analyze 13C MRS data, particularly two-compartment neuronal-glial models to measure the "glutamate-glutamine cycle". This would provide a non-invasive measurement of glutamatergic neurotransmission.
  • To explore the potential of hyperpolarized 13C for the study of brain metabolism and for the detection of tumors in brain and other tissues.
  • To develop new methodologies for 1H MRS and 1H MRSI at very high-field for the measurement of metabolite concentrations ("neurochemical profile") with improved spatial and temporal resolution.
  • International Society of Magnetic Resonance in Medicine
  • International Society of Neurochemistry

Society Memberships:

  • International Society of Magnetic Resonance in Medicine
  • International Society of Neurochemistry

Selected Publications:

  1. Henry P-G, Tkac I, Gruetter R: 1H-localized broadband 13C NMR spectroscopy of the rat brain in vivo at 9.4 Tesla. Magn Reson Med 2003; 50:684-692
  2. Henry P-G, Oz G, Provencher S, Gruetter R: Toward Dynamic isotopomer analysis in the rat brain in vivo: Automatic quantitation of 13C NMR spectra using LCModel. NMR Biomed 2003; 16:400-412
  3. Deelchand D, Ugurbil K, Henry P-G. Investigating Brain Metabolism at High Fields using Localized 13C NMR Spectroscopy without 1H Decoupling. Magn Reson Med 2006; 55(2):279-286
  4. Henry P-G, Marjanska M, Walls JD, Valette J, Gruetter R, Ugurbil K. POCE NMR Spectroscopy in Strongly Coupled Second Order Spin Systems. Magn Reson Med 2006; 55(2):250-257
  5. Henry P-G, Adriany G, Deelchand DK, Gruetter R, Marjanska M, Oz G, Seaquist ER, Shestov A, Ugurbil K: In vivo 13C NMR Spectroscopy and Metabolic Modeling in the Brain: A Practical Perspective. Magn Reson Imag 2006; 24(4):527-539
  6. Shestov AA, Valette J, Ugurbil K, Henry PG. On the Reliability of 13C Metabolic Modeling with Two-Compartment Neuronal-Glial Models. J Neurosci Res 2007; Epub ahead of print.
  7. Henry PG, Russeth KP, Tkac I, Drewes LR, Andrews MT, Gruetter R. Brain energy metabolism and neurotransmission at near-freezing temperatures: in vivo 1H MRS study of a hibernating mammal. J. Neurochem 2007; 101(6):1505-1515
  8. Valette J, Park JY, Gröhn O, Ugurbil K, Garwood M, Henry PG. Spectroscopic imaging with volume selection by unpaired adiabatic p pulses: theory and application. J Magn Reson 2007; in press