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Ivan Tkac

Assistant Professor
2-124 CMRR

Dr. Ivan Tkáč is an Assistant Professor in the Departments of Radiology at the University of Minnesota. He received his master’s and PhD degree in physical chemistry from Comenius University in Bratislava, Slovakia. He moved to the Institute of Inorganic Chemistry, where he specialized in high resolution liquid and solid state NMR spectroscopy. In 1992, he was recruited to the newly established MRI center at the Derer University Hospital in Bratislava to launch the research program focused on in vivo NMR spectroscopy. In 1997, he move to the Center for Magnetic Resonance Research at the University of Minnesota, where his primary research interests have been and are still focused on the development and application of in vivo NMR spectroscopy of brain at ultra high magnetic fields.

Research Interests:

  • Methodology of in vivo NMR spectroscopy at ultra-high magnetic fields: automatic shimming, pulse sequences, data processing, metabolite quantification
  • Neurochemical processes in humans and experimental animals under normal and pathological conditions using NMR spectroscopy at ultra-high magnetic fields
  • Neurochemistry of the developing rat brain: effects of the iron deficiency, hypoxia-ischemia and hypoglycemia using in vivo 1H NMR spectroscopy
  • Longitudinal neurochemical profiling in transgenic mouse models of Huntington’s disease using in vivo 1H NMR spectroscopy

Selected Publications:

Rao R, Ennis K, Long JD, Ugurbil K, Gruetter R, Tkac I. Neurochemical Changes in the Developing Rat Hippocampus During Prolonged Hypoglycemia. J Neurochem 2010; 114:728-38.

Tkac I, Oz O, Adriany G, Ugurbil K, Gruetter R. In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T. Magn Reson Med 2009; 62: 868-879.

Tkac I, Dubinsky JM, Keene CD, Gruetter R, Low WC, Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy. J Neurochem 2007; 100: 1397–1406.

Mangia S, Tkac I, Van de Moortele PF, Maraviglia B, Ugurbil K, Sustained neuronal activation raises oxidative metabolism to a new steady state level: evidence from 1H NMR spectroscopy in the human visual cortex. J Cereb Boold Flow Metab 2007; 27: 1055-1063.

Tkac I, Gruetter R, Methodology of 1H NMR spectroscopy of the human brain at very high magnetic fields. App Magn Reson 2005; 29: 139-157.

Tkac I, Henry PG, Andersen P, Keene CD, Low WC, Gruetter R. Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 tesla. Magn Reson Med 2004; 52: 478-484.

Tkac I, Rao R, Georgieff MK, Gruetter R. Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy. Magn Reson Med 2003; 50: 24-32.

Tkac I, Andersen P, Adriany G, Merkle H, Ugurbil K, Gruetter R. In vivo 1H NMR spectroscopy of the human brain at 7 T. Magn Reson Med 2001; 46: 451-456.

Gruetter R, Tkac I. Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 2000; 43: 319-323.

Tkac I, Starcuk Z, Choi IY, Gruetter R. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 1999; 41: 649-656.

Pfeuffer J, Tkac I, Provencher SW, Gruetter R. Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time 1H NMR spectra of the rat brain. J Magn Reson 1999; 141: 104-120.