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Jianyi Zhang, MD, Ph.D.

Professor of Medical and Biomedical Engineering

University Directory

Jianyi (Jay) Zhang (zhang047@umn.edu) is a Professor of Medicine and Biomedical Engineering, Division of Cardiology, Department of Medicine, University of Minnesota Medical school. He graduated Shanghai Medical University, Shanghai, PRC; received Master of Science, School of Engineering, Tufts University, Medford, Massachusetts; and Biomedical Engineering, Institute of Technology Graduate School, University of Minnesota. Dr. Zhang received Post-doctoral training in Cardiology, University of Minnesota. Research Interests include myocardial energetics in hearts with postinfarction LV remodeling and congestive heart failure, biomaterials, and Stem Cells for Cardiac Repair. Dr. Zhang received an Established Investigator Award ( EIA, 1996) from American Heart Association (AHA) and NIH First Award from National Institutes of Health (FIRST, 1994). He is currently a principal investigator (PI) of three RO1 grants from NIH through 2016 in the fields of Myocardial Bioenergetics, biomaterial and Stem cells for Cardiac Repair, respectively; he also Co-PI of 2 other program grants. Over the years, Zhang research lab has trained more than 40 trainees (PhD, Post-Doc, residents, and cardiology fellows), and led 11 PhDs in biomedical engineering, physiology, or electrical engineering. Dr. Zhang is currently advisor to three PhD students earning their PhD in Biomedical Engineering, Physiology, or Electrical engineering, respectively. Professional Organizations: Fellow members in American Physiological Society, American Heart Association. Reviewer on NIH study sections (MIM, Charter member); Scientific Journal editorial board member for: Circulation Research, American Journal of Physiology.

Research Interests:

Research Projects within the Zhang Laboratory:

  • Fabrication of human cardiac tissue patch using human induced pluripotent stem cells and PEGylated fibrin 3D porous biomaterials
  • Stem Cell Therapy for Myocardial Repair utilizing both vascular progenitor cells and cardiac myocytes progenitor cells derived from human induced pluripotent stem cells (hiPSCs) in a porcine xenograft model to examine myocardial regeneration potential of hiPSCs
  • Bioenergetics in Hypertrophied and Remodeled Left Ventricle to elucidate for the first time, the transmural gradient of ATP turnover rate via both CK and ATPase in the in vivo LVH hearts using the recently established novel NMR saturation transfer technologies

Selected Publications:

Xiong Q, Du F, Zhang P, Chen W, Zhang J (2011). ATP production rate via CK or ATP synthase in vivo: a novel superfast magnetization saturation transfer method . Circulation Research 108(6):653-63

Zhang J (2011). Seamless networks of myocardial bioenergetics. J Physiol. 589(Pt 21):5013-4

Zhang EY, Xiong Q, Ye L, Suntharalingam P , Wang X, Astle CM, Zhang J , Harrison DE (2012). Fetal myocardium in the kidney capsule: an in vivo model of repopulation of myocytes by bone marrow cells. PLoS One. Volume 7, Issue 2

Xiong Q, Ye L, Zhang P, Lepley M, Swingen C, Kauffman DS , Zhang J (2012). Bioenergetic and functional consequences of cellular therapy: activation of endogenous cardiovascular progenitor cells. Circulation Research. 111(4):455-68. Epub 2012 Jun 21.PMID:22723295