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Silvia Mangia

2-166 CMRR

Dr. Mangia is a Professor in the Department of Radiology at the University of Minnesota. She got her master degree in Physics (1999), the Ph.D. in Biophysics (2003) and the title of "Specialist in Medical Physics" (2005) at the University of Rome "La Sapienza" (Italy). Since 2004 she has been working at the Center for Magnetic Resonance Research (CMRR).

Research Interests:

  • Functional studies of human brain metabolism under increased or decreased neuronal activity
  • Neurovascular coupling and neuro-glia interactions
  • Oxidative and non-oxidative brain metabolism; glucose and lactate metabolism
  • Novel MR contrasts based on rotating frame relaxation measurements, magnetization transfer and chemical exchange
  • Applications of novel MRI/MRS protocols for studies of neurological diseases as Parkinson’s disease, schizophrenia, multiple sclerosis
  • Measurements of blood flow with arterial spin labeling methods, and their application to diseases as diabetes
  • Proton NMR Spectroscopy at high fields
  • Resting state fMRI, especially in relation to brain metabolism

Selected Publications:

Mangia S, Traaseth N J, Veglia G, Garwood M, Michaeli S. “Probing slow protein dynamics by adiabatic R and RNMR experiments”, Journal of the American Chemical Society 2010; 132:9979–9981. PMCID: PMC2929914 [Available on 2011/7/1].

Mangia S, Liimatainen T, Garwood M, Michaeli S. “Rotating frame relaxation during adiabatic pulses versus conventional spin-lock: simulations and experimental results at 4T”, Magnetic Resonance Imaging 2009; 27:1074–1087. PMCID: PMC2746880.

Mangia S, Simpson IA, Vannucci SJ, Carruthers A. “The in vivo neuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation”, Journal of Neurochemistry 2009; 109 (Suppl. 1):55–62. PMCID: PMC2679179.

Mangia S, Giove F, TkacI, Logothetis NK, Henry P-G, Olman CA, Maraviglia B, Di Salle F, Ugurbil K. “Metabolic and hemodynamic events following changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings”, Journal of Cerebral Blood Flow and Metabolism 2009; 29:441–463. PMCID: PMC2743443.

Mangia S, Tkac I, Logothetis NK, Gruetter R, Van de Moortele P-F, Ugurbil K. “Dynamics of lactate concentration and BOLD effect in the human vi.sual cortex during repeated identical stimuli”, Journal of Neuroscience Research 2007; 85:3340–3346.

Mangia S, Tkac I, Gruetter R, Van De Moortele P-F, Maraviglia B, Ugurbil K. “Sustained neuronal activation raises oxidative metabolism to a new steady state level: evidence from 1H NMR spectroscopy in the human visual cortex”, Journal of Cerebral Blood Flow and Metabolism 2007; 27:1055–1063.

Mangia, Di Salle F, Garreffa G, Esposito F, Giove F, Cirillo S, Scarabino T, Morrone R, Maraviglia B. “Perfusion-based and BOLD-based fMRI in the study of a human pathological model for task-related flow reductions”, Brain Research Bulletin 2004; 63:1–5.

Mangia S, Garreffa G, Bianciardi M, Giove F, Di Salle F, Maraviglia B. “The aerobic brain: lactate consumption at the onset of neural activity”, Neuroscience 2003; 118:7–10.