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Pierre-François Van de Moortele, MD, PhD

Associate Professor
2-134 CMRR
612-626-2001
vande094@umn.edu

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First in-vivo MRI acquisition in a human subject at 10.5 Tesla

In the late morning of Dec 14th, 2017, the first in-vivo MR images even obtained in a human subject at 10.5 Tesla in an MR scanner were collected at CMRR.

Research Interests:

Each topic has a main focus at 7T and/or 10.5T
  1. Multi-Channel High Performance RF coil for the Human Head at 10.5T 
    • Transmit B1 management at Ultra High Field (Body and Brain applications) 
    • fast multi channel B1 Mapping
    • fast multi channel B1 Shimming
    • RF pulse design in parallel Excitation with SAR constraints
  2. High Resolution Structural and Functional Brain Imaginga
    • High resolution MRI at the skull basis (Trigeminal Nerve)
    • High resolution structural of the Limbic System (Hippocampus) 
  3. Vasculature imaging (Brain / Body)
    • MPRAGE based Angiography
    • Time of Flight based Angiography (Brain)
    • 4D Flow Imaging (intracerebral, heart, aorta) 
  4. Multi-Probe Magnetic Field Real Time Monitoring 
    • Eddy current correction in Connectome-like diffusion weighted MRI at 7T 
    • Physiologically induced real time field variations (respiration, motion,...) 

Selected Publications:

Ma R, Akçakaya M, Moeller S, Auerbach E, Uğurbil K, Van de Moortele P-F.
A field-monitoring-based approach for correcting eddy-current-induced artifacts of up to the 2nd spatial order in human-connectome-project-style multiband diffusion MRI experiment at 7T: A pilot study. NeuroImage 2020;216:116861.

Ma RY, Henry TR, Van de Moortele PF.
Eliminating susceptibility induced hyperintensities in T1 w MPRAGE brain images at 7 T. Magnetic resonance imaging 2019;63:274-279.

Wu X, Tian J, Schmitter S, Vaughan JT, Ugurbil K, Van de Moortele PF.
Distributing coil elements in three dimensions enhances parallel transmission multiband RF performance: A simulation study in the human brain at 7 Tesla. Magn Reson Med 2016;75(6):2464-2472.

Webb AG, Van de Moortele PF.
The technological future of 7 T MRI hardware. NMR Biomed 2016;29(9):1305-1315.

Wu, X., Schmitter, S., Auerbach, E., Moeller, S., Ugurbil, K. & Van de Moortele, P.-F.
Simultaneous multi-slice multi-band parallel RF excitation with independent slice-specific transmit B1 homogenization. (in press) Magn Reson Med.

Schmitter S, Schnell S, Ugurbil K, Markl M, Van de Moortele PF.
Towards high-resolution 4D flow MRI in the human aorta using kt-GRAPPA and B1+ shimming at 7T. J Magn Reson Imaging 2016;44(2):486-499.

Boulant N, Wu X, Adriany G, Schmitter S, Ugurbil K, Van de Moortele PF.
Direct control of the temperature rise in parallel transmission by means of temperature virtual observation points: Simulations at 10.5 tesla. Magn Reson Med 2016;75(1):249-256.

Schmitter, S., Wu, X., Adriany, G., Auerbach, E. J., Ugurbil, K. & Van de Moortele, P. F.
Cerebral TOF angiography at 7T: Impact of B shimming with a 16-channel transceiver array. (2013) Magn Reson Med 2, early view

Wu X, Zhang X, Tian J, Schmitter S, Hanna B, Strupp J, Pfeuffer J, Hamm M, Wang D, Nistler J, He B, Vaughan TJ, Ugurbil K, Van de Moortele PF.
Comparison of RF body coils for MRI at 3 T: a simulation study using parallel transmission on various anatomical targets. NMR Biomed 2015;28(10):1332-1344.

Wu X, Schmitter S, Auerbach EJ, Ugurbil K, Van de Moortele PF.
A generalized slab-wise framework for parallel transmit multiband RF pulse design. Magn Reson Med 2015;75(4):1444-1456.

Schmitter S, Wu X, Ugurbil K, Van de Moortele PF.
Design of parallel transmission radiofrequency pulses robust against respiration in cardiac MRI at 7 Tesla. Magn Reson Med 2015;74(5):1291-1305.

Schmitter S, Wu X, Auerbach EJ, Adriany G, Pfeuffer J, Hamm M, Ugurbil K, van de Moortele PF.
Seven-tesla time-of-flight angiography using a 16-channel parallel transmit system with power-constrained 3-dimensional spoke radiofrequency pulse design. Invest Radiol 2014;49(5):314-325.

Wu X, Schmitter S, Auerbach EJ, Ugurbil K, Van de Moortele PF.
Mitigating transmit B 1 inhomogeneity in the liver at 7T using multi-spoke parallel transmit RF pulse design. Quant Imaging Med Surg 2014;4(1):4-10.

Metzger, G. J., Auerbach, E. J., Akgun, C., Simonson, J., Bi, X., Ugurbil, K. & van de Moortele, P. F.
Dynamically applied B1+ shimming solutions for non-contrast enhanced renal angiography at 7.0 Tesla. (2013) Magn Reson Med 69, 114-126. PMCID: 3387512

De Martino, F., Moerel, M., van de Moortele, P. F., Ugurbil, K., Goebel, R., Yacoub, E. & Formisano, E.
Spatial organization of frequency preference and selectivity in the human inferior colliculus. (2013) Nature communications 4, 1386. PMCID: 3556928

Wu X, Schmitter S, Auerbach E, Moeller S, Ugurbil K, Van de Moortele P-F.
Simultaneous multi-slice multi-band parallel RF excitation with independent slice-specific transmit B1 homogenization. Magnetic Resonance in Medicine 2013;70(3):630-638.

Wu X, Adriany G, Ugurbil K, Van de Moortele PF.
Correcting for strong eddy current induced B0 modulation enables two-spoke RF pulse design with parallel transmission: demonstration at 9.4T in the human brain. PloS one 2013;8(10):e78078.

Schmitter S, Wu X, Adriany G, Auerbach EJ, Ugurbil K, Van de Moortele PF.
Cerebral TOF angiography at 7T: Impact of B shimming with a 16-channel transceiver array. Magn Reson Med 2013;2(10):24749.

Schmitter S, DelaBarre L, Wu X, Greiser A, Wang D, Auerbach EJ, Vaughan JT, Ugurbil K, Van de Moortele PF.
Cardiac imaging at 7 Tesla: Single- and two-spoke radiofrequency pulse design with 16-channel parallel excitation. Magn Reson Med 2013;70(5):1210-1219.

Metzger GJ, Auerbach EJ, Akgun C, Simonson J, Bi X, Ugurbil K, van de Moortele PF.
Dynamically applied B1+ shimming solutions for non-contrast enhanced renal angiography at 7.0 Tesla. Magn Reson Med 2013;69(1):114-126.

Ellermann J, Goerke U, Morgan P, Ugurbil K, Tian J, Schmitter S, Vaughan T, Van De Moortele PF.
Simultaneous bilateral hip joint imaging at 7 Tesla using fast transmit B(1) shimming methods and multichannel transmission - a feasibility study. NMR Biomed 2012;25(10):1202-1208.

Schmitter S, Bock M, Johst S, Auerbach EJ, Ugurbil K, Van de Moortele PF.
Contrast enhancement in TOF cerebral angiography at 7 T using saturation and MT pulses under SAR constraints: impact of VERSE and sparse pulses. Magn Reson Med 2012;68(1):188-197.

Henry TR, Chupin M, Lehericy S, Strupp JP, Sikora MA, Sha ZY, Ugurbil K, Van de Moortele PF. 

Hippocampal sclerosis in temporal lobe epilepsy: findings at 7 T(1). Radiology 2011;261(1):199-209.

Wu X, Vaughan JT, Ugurbil K, Van de Moortele PF.
Parallel excitation in the human brain at 9.4 T counteracting k-space errors with RF pulse design. Magn Reson Med 2010;63(2):524-529.

Wu X, Akgün C, Vaughan JT, Andersen P, Strupp J, Ugurbil K, Van de Moortele P-F.
Adapted RF Pulse Design for SAR Reduction in Parallel Excitation with Experimental Verification at 9.4 Tesla. Journal of Magnetic Resonance 2010;205:161-170.

Van de Moortele PF, Auerbach EJ, Olman C, Yacoub E, Ugurbil K, Moeller S.
T1 weighted brain images at 7 Tesla unbiased for Proton Density, T2* contrast and RF coil receive B1 sensitivity with simultaneous vessel visualization. Neuroimage 2009;46(2):432-446.

Metzger GJ, Snyder C, Akgun C, Vaughan T, Ugurbil K, Van de Moortele PF.
Local B1+ shimming for prostate imaging with transceiver arrays at 7T based on subject-dependent transmit phase measurements. Magn Reson Med 2008;59(2):396-409.

Wiesinger F, Van de Moortele PF, Adriany G, De Zanche N, Ugurbil K, Pruessmann KP.
Potential and feasibility of parallel MRI at high field. NMR Biomed 2006;19(3):368-378.

Van de Moortele PF, Akgun C, Adriany G, Moeller S, Ritter J, Collins CM, Smith MB, Vaughan JT, Ugurbil K.
B1 destructive interferences and spatial phase patterns at 7 T with a head transceiver array coil. Magn Reson Med 2005;54(6):1503-1518.

Van de Moortele PF, Pfeuffer J, Glover GH, Ugurbil K, Hu X. Respiration-induced B0 fluctuations and their spatial distribution in the human brain at 7 Tesla. Magn Reson Med 2002;47(5):888-895.

Van de Moortele PF, Cerf B, Lobel E, Paradis AL, Faurion A, Le Bihan D. Latencies in fMRI time-series: effect of slice acquisition order and perception. NMR Biomed 1997;10(4-5):230-236.