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Shalom Michaeli



Research Interests:


I have a broad background and experience in the field of Magnetic Resonance (MR). My current research is focused on the relaxations during radiofrequency irradiation and development of non-invasive contrast methods for MR imaging and spectroscopy at high magnetic fields (3T and higher). Rotating frame relaxation methods based on frequency swept pulses were first developed in our laboratory at the CMRR in Minnesota. The novel MR contrasts and protocols developed in my group were proven to provide an excellent tool for investigation of neurodegenerative processes in Parkinson’s disease (PD), Multiple Sclerosis (MS), Mucopolysaccharidosis (MPS) - I as well as cancer and stroke. It has been more than 15 years that we applied our rotating frame relaxation methods T1rho and T2rho to investigate neurological disorders including PD and MS. Our recent development of novel method entitled Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank n (RAFFn) which comprises two relaxation pathways, T1rho and T2rho, allowed to probe slow molecular motion in vivo. Overall, these methodologies allow generating flexible non-invasive MRI contrasts and are designed to assess microstructural tissue signatures. I serve as PI and Co-I of several NIH and European grants, and successfully lead several projects in application to humans and animals. Another research activities are focused to design and optimization of the orientation selective stimulation (OSS) strategies for neuromodulation, and in particular on application of this novel methodology to deep brain and spinal cord stimulation (DBS and SCS, respectively). This development has an impact on neuromodulation and biomedical research, and has high potential for improving clinical DBS strategies.


Selected Publications:

"MRI Contrast from Relaxation Along a Fictitious Field (RAFF)” T. Liimatainen, D. J. Sorce, M. Garwood, S. Michaeli Magn Reson Med, 2010, 64(4): 983-94

“Probing Slow Dynamics by Adiabatic R and R NMR Experiments” S. Mangia, N.J. Traaseth,G. Veglia, M. Garwood, S. Michaeli J. Am. Chem. Soc, 2010, 132(29): 9979-81

“Frequency Offset Dependence of Rotating Frame Relaxation Rate Constants: relevance to MRS investigations of metabolite dynamics in vivo”

S. Mangia, T. Liimatainen, M. Garwood, Pierre-Gilles Henry, Dinesh Deelchand, S. Michaeli NMR Biomed, in press

“Proton Resonance Frequency Shift Coefficient of Thermo-Chemical Ablation Salt Solutions for MR Thermometry” D. Shrivastava, T. Hanson, U. Goerke, M. Shenoi, S. Michaeli, J.T. Vaughan, E.Cressman International Journal of Hyperthermia, 2010, submitted

“T and TMRI in the evaluation of Parkinson’s disease” Nestrasil, S. Michaeli, T. Liimatainen ,C. E. Rydeen , C. M. Kotz, J. P. Nixon , T. Hanson , P. J. Tuite J Neurol, 2010, 257,964-968

“Theoretical Simulations of Rotating Frame Relaxations during Adiabatic Pulses versus Conventional Spin-lock” S. Mangia, T. Liimatainen, D. J. Sorce, K. Ugurbil, M. Garwood, S. Michaeli Magn Reson Imaging 2009; 27:1074-1087

“ Detection of Neuronal Loss using T MRI Assessment of 1H2O Spin Dynamics in the Aphakia Mouse” S. Michaeli, T. Burns, E. Kudishevich, T. Hanson, D. Sorce, M. Garwood, W. C. Low J Neurosci Meth 2009; 177:160-167

“Quantitative assessment of water pools by T and T MRI in acute cerebral ischemia of the rat” K. T. Jokivarsi, J. P. Niskanen, S. Michaeli, H. I. Gröhn, M. Garwood, R. A. Kauppinen, O. H. Gröhn J Cerebr Blood F Met 2009; 29:206-16

“Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T and T” A. Sierra, S. Michaeli, J. P. Niskanen, P. K. Valonen, H. I. Gröhn, S. Ylä-Herttuala, M. Garwood, O. H. Gröhn Magn Reson Med, 2008; 59:1311-1319

“Relaxation During Adiabatic Radiofrequency Pulses” D. Sorce, S. Michaeli, M. Garwood Curr Anal Chem 2007; 3:239-251

“T and T Adiabatic Relaxations and Contrasts” S. Michaeli, D. Sorce, M. Garwood Curr Anal Chem 2008; 4:8-25

“Assessment of Brain Iron and Neuronal Integrity in Patients with Parkinson’s Disease Using Novel MRI Contrasts” S. Michaeli, G. Öz, D. Sorce, M. Garwood, K. Ugurbil, S. Majestic, P. Tuite Movement Disord, 2007; 22:334-340

“T MRI Contrast in the Human Brain: Modulation of the Longitudinal Rotating Frame Relaxation Shutter‑Speed During an Adiabatic RF Pulse” S. Michaeli, D. Sorce, C. Springer, Jr., K. Ugurbil, M. Garwood J Magn Reson, 2006; 181:135-147

“The time-dependence of exchange-induced relaxation during modulated radio frequency pulses” D. Sorce, S. Michaeli, M. Garwood J Magn Reson, 2006; 179:136-139

“Quantitative T and adiabatic Carr-Purcell T2 magnetic resonance imaging of human occipital lobe at 4T” H. Gröhn, S. Michaeli, M. Garwood, R. Kauppinen, O. Gröhn Magn Reson Med, 2005; 54:14-19

“Exchange-Influenced T Contrast in Human Brain Images Measured with Adiabatic RF Pulses” S. Michaeli, H. Gröhn, O. Gröhn, D. J. Sorce, R. Kauppinen, C. S. Springer, K. Ugurbil, M.Garwood Magn Reson Med, 2005; 53:823-829

“Transverse Relaxation in the Rotating Frame Induced by Chemical Exchange” S. Michaeli, D. J. Sorce, D. Idiyatullin, K. Ugurbil, M. Garwood J Magn Reson, 2004; 169:293-299

“Product Operator Analysis of the Influence of Chemical Exchange on Relaxation Rates” D. Idiyatullin, S. Michaeli, M. Garwood J Magn Reson, 2004; 171:330-337

“T2 Relaxation Study of Water, N-acetylaspartate (NAA) and Creatine (Cr) in Human Brains using Hahn and Carr-Purcell Spin-Echoes at 4T and 7T” S. Michaeli, M. Garwood, X. H. Zhu, L. DelaBarre, K. Ugurbil, W. Chen Magn Reson Med, 2002; 47:629-633

“In-vivo T2 Measurement in the Human Occipital Lobe at 4T and 7T by Carr-Purcell MR Imaging: Detection of Microscopic Susceptibility Contrast” R. Bartha, S. Michaeli, H. Merkle, G. Adriany, P. Anderson, W. Chen, K. Ugurbil, M. Garwood Magn Reson Med, 2002; 47: 742-750

“Different Excitation and Reception Distributions with a Single-Loop Transmit-Receive Surface Coil near a Head-Sized Spherical Phantom at 300 MHz” C. M. Collins, Q. X. Yang, J. H. Wang, X. Zhang, H. Liu, S. Michaeli, X. H. Zhu, G. Adriany, J. T. Vaughan, P. Anderson, H. Merkle, K. Ugurbil, M. B. Smith, W. Chen Magn Reson Med, 2002; 45:1026-1028

“Triplet Dynamics of Conformationally Distorted Porphyrins in Isotropic Liquids and Liquid Crystals. Time-Resolved Electron Paramagnetic Resonance Study” S. Michaeli, S. Soffer, H. Levanon and M. Senge J Phys Chem A, 1999; 103:1950-1957

“Photoinduced Electron Transfer Between N,N,N',N',-tertamethylbenzidine(NTMB). Fourier Transform Electron Paramagnetic Resonance Study” S. Michaeli, V.Meiklyar, H. Levanon, B. Endeward and K. Möbius Res Chem Intermed 1997; 23:505-517

“Photoexcited Electron Transfer from Triplet Fullerene, 3C60, to Tetracyanoethylene. Fourier Transform Electron Paramagnetic Resonance Study” S. Michaeli, V. Meiklyar, M. Schulz, K. Möbius, H. Levanon J Phys Chem1994; 98:7444-7447.

“Triplet State and Dynamics of Photoexcited C70” H. Levanon, V. Meiklyar, S. Michaeli, D. Gamlie J Am Chem Soc, 1993; 115:8722-8727

“Dynamics of 3C60 Probed by Electron Paramagnetic Resonance. Motional Analysis in Isotropic and Liquid Crystalline Matrices” A. Regev, D. Gamliel, V. Meiklyar, S. Michaeli, H. Levanon J Phys Chem, 1993; 97:3671-3679

“Control of Porphyrin Orientation in Thermotropic Liquid Crystals by Molecular Design. A Time-Resolved EPR Study” S. Michaeli, M. Hugerat, H. Levanon, M. Bernitz, A. Natt, R. Neumann J Am Chem Soc, 1992; 114:3612-3618

“Paramagnetic States and Dynamics of Photoexcited C60” H. Levanon, V. Meiklyar, A. Michaeli, S. Michaeli, A. Regev J Phys Chem, 1992; 96:6128-6131

“Controlled Orientation of Porphyrins by Molecular Design in Thermotropic Liquid Crystals. A Time-resolved EPR Study” R. Neumann, M. Hugerat, S. Michaeli, A. Natt, M. Bernitz, H. Levanon Chem Phys Lett, 1991; 182:249-252

“Solvent Effect in Randomly and Partially Oriented Triplet of the Sapphyrin Dication. Optical and Fast EPR-Magnetophotoselection Measurements” A. Regev, S. Michaeli, H. Levanon, M. Cyr, J. L. Sessler J Phys Chem, 1991; 95:9121-9129

“The Photoinduced Triplet State of Sapphyrin Dication. Unusual Spin Alignment in Monomers and Spin Delocalisation in Dimers” H. Levanon, A. Regev, S. Michaeli, T. Galili, M. Cyr, J. L. Sessler Chem Phys Lett, 1990; 174:235-240