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Wei Chen, Ph.D.


1-211E CMRR

Research Interests:

Dr. Wei Chen is a Professor in the Departments of Radiology and Biomedical Engineering at the University of Minnesota. He received his B.S. degree in physical chemistry at Fudan University in Shanghai, China. In 1985, he joined Professor Ackerman's lab as a graduate student at Washington University in St. Louis and received his Ph.D. in 1990. He spent three years as a postdoctoral fellow and research associate in Professor Shulman's lab at Yale University Medical School. In 1994, he joined the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota and became a full professor in 2002. His research focuses on development of magnetic resonance imaging (MRI)/spectroscopy (MRS) methodologies and technologies for noninvasively studying cellular metabolism, bioenergetics, function and dysfunction of the brain and other organs. He has been a principal investigator for a large number of NIH RO1 grants, served as grant reviewer for many funding organizations and editorial boards for imaging journals.

Selected Publications:

Chen W, Novotny EJ, Zhu XH, Rothman DL, Shulman RG. Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proc Natl Acad Sci USA 1993;90:9896-9900.

Chen W, Zhu XH, Thulborn KR, Ugurbil K. Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging. Proc Natl Acad Sci USA 1999;96:2430-2434.

Ogawa S, Lee TM, Stepnoski R, Chen W, Zhu XH, Ugurbil K. An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds. Proc Natl Acad Sci USA 2000;97:11026-11031.

Zhu XH, Zhang Y, Tian RX, Lei H, Zhang N, Zhang X, Merkle H, Ugurbil K, Chen W. Development of 17O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field. Proc Natl Acad Sci USA 2002;99:13194-13199.

Lei H, Ugurbil K, Chen W. Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy. Proc Natl Acad Sci USA 2003;100:14409-14414.

Du F, Zhu XH, Zhang Y, Friedman M, Zhang N, Ugurbil K, Chen W. Tightly coupled brain activity and cerebral ATP metabolic rate. Proc Natl Acad Sci USA 2008;105:6409-6414.

Zhu XH, Zhang N, Zhang Y, Ugurbil K, Chen W. New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain. J Cereb Blood Flow Metab 2009;29:10-18.

Zhang N, Zhu XH, Zhang Y, Park JK, Chen W. High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleus. Neuroimage 2010;50:1456-1463.

Liu X, Zhu XH, Zhang Y, Chen W. Neural origin of spontaneous hemodynamic fluctuations in rats under burst-suppression anesthesia condition. Cereb Cortex 2011;21:374-384.

Zhu XH, Qiao H, Du F, Xiong Q, Liu X, Zhang X, Ugurbil K, Chen W. Quantitative imaging of energy expenditure in human brain. Neuroimage 2012;60:2107-2117.

Cui W, Zhu XH, Vollmers ML, Colonna ET, Adriany G, Tramm B, Dubinsky JM, Oz G. Non-invasive measurement of cerebral oxygen metabolism in the mouse brain by ultra-high field 17O MR spectroscopy. J Cereb Blood Flow Metab 2013;33:1846-1849.

Lu M, Zhu XH, Zhang Y, Chen W. Intracellular redox state revealed by in vivo 31P MRS measurement of NAD+ and NADH contents in brains. Magn Reson Med 2014;71:1959-1972.