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Xiufeng Li, Ph. D.


Assistant Professor
2-158 CMRR

Xiufeng Li, Ph.D., is an Assistant Professor at the Center for Magnetic Resonance Research (CMRR), Department of Radiology, at the University of Minnesota. Dr. Li received his Bachelor of Science in Mechanical & Manufacturing Engineering (1992) and Master of Science in Computer Aided Designed (CAD) and Computer Aided Manufacturing (CAM) (1995) from Beijing Unniversity of Aeronautics and Astronautics (BUAA). Dr. Li’s Ph.D. research work was conducted under the mentorship of Dr. Richard R. Briggs with the focus on MRI physics and Neuroimaging (2003-2009), and continued after his graduation as a Senior Research Scientist (2009-2010) at the University of Texas Southwestern Medical Center at Dallas. Dr. Li joined CMRR as a research associate, and then works as an Assistant Professor to contribute his expertise and experience for applying ASL methods in the brain and the body at both 3T and 7T (2010-present).

Dr. Li's research focuses on the development and optimization of non-contrast enhanced (NCE) perfusion MRI technique-arterial spin labeling (ASL), as well as other MRI approaches (e.g. NCE angiography, T1 and T2 relaxometry) at both 3T and 7T, and on the application of these techniques to understand organ function and pathophysiology of diverse diseases, e.g. Gulf War Illness, Stroke, Prostate Cancer, Chronic Kidney Disease, and Cardiovascular Disease.

Research Interests:

  • Development and optimization of non-contrast enhanced perfusion imaging technique, arterial spin labeling (ASL), at 3T and 7T in both the brain and the abdominal organs, e.g. the prostate, kidneys and the heart
  • Customizing and utilizing novel techniques for ASL imaging: multiband EPI (MB-EPI), dynamical B1 shimming, multi-channel transmit/receiving coils, etc.
  • Application of ASL imaging methods, as well as other imaging modalities (NCE angiography, diffusion-weighted imaging, T1 and T2 relaxometry, etc.), to clinical studies with the ultimate goal to improve healthcare

Selected Publications:

  1. Li X, Sarkar SN, Purdy DE, Spence JS, Haley RW, Briggs RW. Anterioposterior perfusion heterogeneity in human hippocampus measured by arterial spin labeling MRI. NMR Biomed. 2013 Jun; 26(6):613-21. doi: 10.1002/nbm.2898.
  2. Li X, Metzger G. Feasibility of Measuring Prostate Perfusion with Arterial Spin Labeling. NMR Biomed. 2013 Jan; 26(1):51-7. doi: 10.1002/nbm.2818.
  3. Li X, Spence JS, Buhner DM, Haley RW, Briggs RW. Dynamic physostigmine effects on hippocampus perfusion. J Magn Reson Imaging. 2012;35(2):280-286; doi: 10.1002/jmri.22821.
  4. Li X, Spence JS, Buhner DM, Hart J, Jr., Cullum CM, Biggs MM, Hester AL, Odegard TN, Carmack PS, Briggs RW, Haley RW. Hippocampal dysfunction in Gulf War veterans: investigation with ASL perfusion MR imaging and physostigmine challenge. Radiology 2011;261(1):218-225.
  5. Li X, Sarkar SN, Purdy DE, Haley RW, Briggs RW. Improved quantification of brain perfusion using FAIR with active suppression of superior tagging (FAIR ASST). J Magn Reson Imaging. 2011;34(5):1037-1044; doi: 10.1002/jmri.22734.
  6. Liu P, Aslan S, Li X, Buhner DM, Spence JS, Briggs RW, Haley RW, Lu H. Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness. Neurotoxicology 2011;32(2):242-246.
  7. Crosson B, Ford A, McGregor KM, Meinzer M, Cheshkov S, Li X, Walker-Batson D, Briggs RW. Functional imaging and related techniques: an introduction for rehabilitation researchers. Journal of rehabilitation research and development 2010;47(2):vii-xxxiv.