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Xiao-Hong Zhu, Ph.D.

1-211E CMRR

Dr. Xiao-Hong Zhu graduated from Fudan University, Shanghai, China in 1985 with a B.S. degree in Chemistry. She came to US in 1987 and obtained a Ph.D. in Chemistry (Department of Chemistry, University of Missouri-St. Louis) at 1991. After graduation, she received postdoctoral training in Professor Robert G. Shulman's lab (Magnetic Resonance Center, Department of Molecular Biophysics and Biochemistry, Yale University) where she started MR related research. Dr. Zhu joined the Center for Magnetic Resonance Research (CMRR) in 1994 working with Prof. K. Ugurbil, SG Kim and W. Chen in developing and utilizing MR imaging and spectroscopy technologies for basic biomedical research; she has over 60 publications in peer-reviewed journals and became an associate professor (w/o tenure track) in the Department of Radiology in 2003.

Research Interests:

  • To develop and improve the in vivo 17O MRS/I techniques at high/ultra-high fields for non-invasively studying oxygen metabolism in normal and diseased tissues;
  • To develop and establish novel in vivo 31P MRS/I techniques at high/ultra-high fields for quantitatively understanding the energy metabolism and NAD/NADH redox state in health and diseases;
  • To implement and integrate various MR and non-MR methods and apply them to different animal models for studying cerebral hemodynamic, metabolic and energetic responses in animal brains under pathophysiological conditions

Selected Publications:

1. Zhu XH, Chen JM, Tu TW, Chen W, Song SK; Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice. Neuroimage. 2013 Jan 1;64:437-47.

2. Zhu XH, Qiao H, Du F, Xiong Q, Liu X, Zhang X, Ugurbil K, Chen W; Quantitative imaging of energy expenditure in human brain. Neuroimage. 2012 May 1;60(4):2107-17.

3. Zhu XH, Chen W; In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field. Prog Nucl Magn Reson Spectrosc. 2011 Nov;59(4):319-35.

4. Zhu XH, Zhang N, Zhang Y, Uğurbil K, Chen W; New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain. J Cereb Blood Flow Metab. 2009 Jan;29(1):10-8.

5. Du F, Zhu XH, Zhang Y, Friedman M, Zhang N, Uğurbil K, Chen W; Tightly coupled brain activity and cerebral ATP metabolic rate. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6409-14.

6. Zhu XH, Zhang Y, Zhang N, Uğurbil K, Chen W; Noninvasive and three-dimensional imaging of CMRO2 in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study. J Cereb Blood Flow Metab. 2007 Jun;27(6):1225-34.

7. Chen W and Zhu XH; Dynamic study of cerebral bioenergetics and brain function using in vivo multinuclear MRS approaches. Concepts in Magnetic Resonance Part A. 2005 Nov;27A(2):84-121.

8. Zhu XH, Zhang Y, Tian RX, Lei H, Zhang N, Zhang X, Merkle H, Uğurbil K, Chen W; Development of 17O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13194-9.

9. Chen W, Zhu XH, Thulborn KR, Uğurbil K; Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2430-4.

10. Zhu XH, Kim SG, Andersen P, Ogawa S, Uğurbil K, Chen W; Simultaneous oxygenation and perfusion imaging study of functional activity in primary visual cortex at different visual stimulation frequency: quantitative correlation between BOLD and CBF changes. Magn Reson Med. 1998 Nov;40(5):703-11.

11. Dassonville P, Zhu XH, Uğurbil K, Kim SG, Ashe J; Functional activation in motor cortex reflects the direction and the degree of handedness. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14015-8.

12. Chen W, Novotny EJ, Zhu XH, Rothman DL, Shulman RG; Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):9896-900.